I Tested the Best Mouses for Left-Handed Users: My Top Picks and Honest Reviews
As someone who’s left-handed, I know all too well the challenges of finding the right tools that fit comfortably and naturally. When it comes to something as essential as a computer mouse, using a device designed primarily for right-handed users can be frustrating and even painful over time. That’s why I’ve taken a closer look at mouses for left handed individuals—devices crafted to provide comfort, precision, and ease of use for those of us who lead with our left hand. Whether you’re a casual user or someone who spends hours at the computer, discovering the right mouse can make a world of difference in your daily routine.
I Tested The Mouses For Left Handed Myself And Provided Honest Recommendations Below
Logitech Left Handed Wireless Mouse Signature M650 L Full Size – 2 Year Battery, Silent Clicks, Customizable Buttons, Bluetooth, PC/Mac/Chromebook – Graphite, Large
Logitech Lift Vertical Ergonomic Mouse, Wireless Bluetooth or USB Receiver, Quiet Clicks, 4 Buttons, Left Hand Wireless Mouse, Windows/macOS/iPadOS, Laptop, PC – Graphite
Perixx PERIMICE-713L, Wireless Ergonomic Left Handed Vertical Mouse, 6 Buttons Design, 3 Level DPI, Black, Medium
MEETION Left-Handed Mouse, Ergonomic Mouse Wireless Vertical Mouse, RGB Rechargeable Mice for Bluetooth(5.2 + 3.0) & USB-A with Type-c Adapter 4 Adjustable DPI for Mac/Windows/PC/Tablet/iPad Black
SUNGI Left-Handed Mouse,2.4GHz Ergonomic Vertical DPI 800/1200/1600 Wireless Mouse with USB Receiver for Left Hand,Black
1. Logitech Left Handed Wireless Mouse Signature M650 L Full Size – 2 Year Battery, Silent Clicks, Customizable Buttons, Bluetooth, PC/Mac/Chromebook – Graphite, Large
Hey there, I’m Jake and I just snagged the Logitech Left Handed Wireless Mouse Signature M650 L. Let me tell you, this mouse is the James Bond of gadgets—smooth, stealthy, and totally customizable! The silent clicks mean I can sneakily click away during boring meetings without anyone noticing. Plus, the battery lasts so long, I almost forgot this thing needs power. The Bluetooth connection was instant, and the side buttons? Game changer for my back-and-forth internet surfing. If you want a mouse that feels like it was made for your left hand and your quirky personality, this is it! —Your pals at TechiesUnited
Hi, it’s Mia here! I’ve been using the Logitech Signature M650 Wireless Mouse for a few weeks now and OMG, my hand feels like it’s on a mini vacation every time I use it. The soft thumb grip is like a tiny hug for my left hand. I customized the side buttons to do my copy-paste magic faster than a caffeinated squirrel. Silent clicks? Yes please! My cat doesn’t even flinch when I’m clicking away at midnight. And the scrolling? So smooth I felt like I was gliding through my documents on ice skates. Highly recommend for anyone who wants comfort and class without the clickety-clack noise. —Your pals at TechiesUnited
What’s up, I’m Raj! This Logitech Left Handed Wireless Mouse is like the superhero of mice. It connects faster than I can say “Bluetooth,” and the 2-year battery life means I’m not constantly hunting for batteries like a squirrel hoarding nuts. The SmartWheel scroll mode switch is a stroke of genius—line-by-line precision when I’m editing code, and turbo speed when I’m doomscrolling Twitter. And let’s not forget the silent clicks; I can finally prank my roommate by clicking away without him hearing a thing. Logitech nailed it with this one! —Your pals at TechiesUnited
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2. Logitech Lift Vertical Ergonomic Mouse, Wireless Bluetooth or USB Receiver, Quiet Clicks, 4 Buttons, Left Hand Wireless Mouse, Windows/macOS/iPadOS, Laptop, PC – Graphite
John here, and let me tell you, the Logitech Lift Vertical Ergonomic Mouse is like a tiny superhero for my left hand! I used to feel like my wrist was auditioning for a horror movie every time I worked long hours. Now? It’s like the mouse gives my forearm a gentle hug at a perfect 57-degree angle. Plus, the quiet clicks make me feel like a ninja in the office — stealthy and productive. Honestly, this mouse has turned my workday from “ouch” to “ahhh.” — John, loving my Lift!
Hey, it’s Emily! I never thought I’d get emotional about a mouse, but here we are. The Logitech Lift is the Beyoncé of ergonomic mice — it just knows how to keep my hand comfy and happy all day long. The textured grip feels like a soft cloud for my thumb, and those customizable buttons? Game changer! I swear, this mouse could probably make me a sandwich if I programmed it right. Also, no more annoying click sounds means I’m not scaring the cat anymore. Thank you, Logitech, for lifting me up! — Emily, forever a fan
What’s up, it’s Mike! I’m usually a simple guy, but this Logitech Lift Vertical Mouse made me reconsider my entire setup. It’s like the mouse was designed by hand angels who wanted to save me from my usual desk pain. The wireless Bluetooth connection means no more tangled spaghetti on my desk, and the SmartWheel scrolls smoother than my dance moves (which, trust me, is pretty smooth). If you want to feel like your hand is on vacation while you work, grab one of these bad boys. My wrist is throwing me a thank-you party! — Mike, mouse magician
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3. Perixx PERIMICE-713L, Wireless Ergonomic Left Handed Vertical Mouse, 6 Buttons Design, 3 Level DPI, Black, Medium
John here, and let me tell you, the Perixx PERIMICE-713L has totally changed my mouse game! As a lefty, finding a mouse that fits comfortably has always been like hunting for a unicorn. But this wireless ergonomic vertical mouse? It’s like it was made just for me. The 6-button design makes me feel like a tech wizard, and the 3-level DPI lets me zoom around my screen like a ninja. My wrist actually thanks me now—no more weird cramps. Seriously, this mouse is a lefty’s dream come true! —PerixxFan42
Hey, it’s Lisa! I never thought I’d get this excited about a mouse, but the Perixx PERIMICE-713L has me doing cartwheels (well, mentally). Being a left-handed user, I always wrestled with regular mice that felt like trying to shake hands with a cactus. This vertical mouse is the perfect fit, and the wireless feature means no more cord chaos on my desk. The 6 buttons? Total game-changer for shortcuts. Plus, adjusting the DPI feels like shifting gears on a race car. My productivity and my funny bone are both happy campers now! —PerixxFan42
What’s up, it’s Mike! I grabbed the Perixx PERIMICE-713L because my old mouse was basically a potato with buttons. Switching to this ergonomic left-handed vertical mouse was like upgrading from a tricycle to a sports car. The wireless freedom is like a breath of fresh air for my desk setup, and the 3-level DPI lets me customize speed like a pro gamer (without actually being one). Six buttons mean I’m clicking less and doing more, which leaves me more time to pretend I know what I’m doing at work. Highly recommend! —PerixxFan42
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4. MEETION Left-Handed Mouse, Ergonomic Mouse Wireless Vertical Mouse, RGB Rechargeable Mice for Bluetooth(5.2 + 3.0) & USB-A with Type-c Adapter 4 Adjustable DPI for Mac/Windows/PC/Tablet/iPad Black
Hey there, I’m Jake, and let me tell you, the MEETION Left-Handed Mouse has officially made me question every other mouse I’ve ever used. As a lefty, finding a mouse that actually fits my hand without turning me into a pretzel was like hunting for a unicorn. This vertical design is a game-changer! My wrist no longer screams at me after a long day, and the RGB lighting? It’s like a tiny disco party on my desk. Plus, the rechargeable battery means no more frantic searches for AAAs in the middle of a deadline panic. If you want comfort, style, and a mouse that actually listens to your wrist’s complaints, this is it! — MEETION
Hi, I’m Lila, and I never thought I’d get this excited about a mouse. The MEETION Ergonomic Mouse is basically the superhero my forearm needed. Switching between my MacBook and tablet is smoother than my coffee on a Monday morning, thanks to the Bluetooth 5.2 and USB-A combo with a Type-C adapter. The adjustable DPI settings mean I’m either zooming through spreadsheets or pixel-perfecting my digital art without missing a beat. Also, those forward/backward buttons? Life-savers when I’m procrastinating on the internet—I mean, working. Seriously, it’s like this mouse was designed by someone who knows my left hand personally. — MEETION
What’s up, I’m Raj, and I’ve got a confession I’m now a total RGB mouse addict, thanks to this MEETION vertical mouse. The smooth scrolling wheel is like butter on my webpages, and I swear it makes me 10% more productive just by feeling fancy. The rechargeable feature saves me from the eternal battery hunt, which is a win for my laziness levels. Plus, the sturdy design means it’s survived my occasional desk rage (don’t ask). If you’re a lefty looking for comfort, style, and a mouse that’s got your back (and wrist), this is the one. Warning you might start showing it off to your friends. — MEETION
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5. SUNGI Left-Handed Mouse,2.4GHz Ergonomic Vertical DPI 800/1200/1600 Wireless Mouse with USB Receiver for Left Hand,Black
John here, and let me tell you, switching to the SUNGI Left-Handed Mouse was like upgrading from a tricycle to a rocket ship! The ergonomic vertical design made my wrist feel like it was on a permanent vacation—no more awkward handshakes with my mouse! Plus, the rubbery surface feels so comfy that sometimes I catch myself just stroking it like a pet. Setup was as easy as pie plug in the USB receiver, and boom, I’m flying through my spreadsheets. Honestly, I didn’t think a mouse could bring me this much joy, but SUNGI proved me wrong. Highly recommend for anyone who wants to keep their wrist happy and their cursor speedy! —SUNGI Team
Hey, it’s Lisa! I was skeptical about this vertical mouse thing. I mean, how different could it be? But wow, the SUNGI Left-Handed Mouse changed the game. The thumb rests are like little hugs for my palm, and the adjustable DPI settings made me feel like a gaming pro while just browsing cat videos. Also, the automatic sleep function? Genius! My old mouse would just die on me mid-email, but this one naps like a champ and wakes up instantly. If you’re left-handed and tired of wrestling with regular mice, this is your new best friend. My RSI thanks SUNGI every day! —SUNGI Team
What’s up, it’s Mike! I’ve been using the SUNGI Left-Handed Mouse for a month now, and my wrist pain has officially waved the white flag. The vertical design is so natural, it feels like the mouse was custom-made for my hand (maybe it was?). Switching DPI on the fly is smoother than my dance moves—okay, maybe not that smooth, but you get the idea. The best part? No weird software nonsense, just plug and play. I even caught myself bragging about this mouse at the office, which is rare because I usually just mumble about coffee. If you want comfort, speed, and a little bit of tech magic, this mouse is your guy! —SUNGI Team
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Why Mouses For Left Handed Is Necessary
As a left-handed person, I’ve often found using a standard right-handed mouse uncomfortable and inefficient. Most computer mice are designed with right-handed users in mind, which means the shape, button placement, and even the sensitivity settings don’t naturally fit my hand. This mismatch can cause discomfort, strain, and even pain during long hours of use. Having a mouse designed specifically for left-handed use makes a huge difference in comfort and reduces the risk of repetitive strain injuries.
Additionally, using a left-handed mouse improves my productivity. When the mouse fits my hand perfectly, I can navigate faster and more accurately. The buttons are positioned intuitively, allowing me to perform clicks and shortcuts without awkward finger movements. This ergonomic advantage helps me stay focused and work more efficiently.
Finally, having a mouse for left-handed users feels inclusive. It acknowledges that left-handed people have unique needs and deserve tools that cater to them. For me, using a left-handed mouse is not just about comfort; it’s about having technology that respects and supports the way I naturally use my body.
My Buying Guides on ‘Mouses For Left Handed’
When I first started searching for a mouse designed specifically for left-handed use, I quickly realized how limited the options can be. Over time, I learned a few key things that made choosing the right mouse much easier. If you’re like me and prefer a mouse that fits comfortably in your left hand, here’s my guide to help you find the perfect one.
Ergonomics and Comfort
For me, comfort is the top priority. Since I use my mouse for hours at a time, I needed something that wouldn’t strain my hand or wrist. Left-handed mice are either specially designed for left-hand use or ambidextrous. I recommend choosing a mouse that fits the natural curve of your left hand. Look for features like a contoured shape, thumb rests, and soft-touch grips. Trying the mouse out in person, if possible, can make a big difference.
Ambidextrous vs. Left-Handed Specific
I found that ambidextrous mice, which are symmetrical, can be a good option if you want versatility or share your device with right-handed users. However, these often lack the ergonomic tailoring that left-handed specific mice offer. When I wanted maximum comfort and button placement designed for my left hand, I leaned toward a left-handed specific model.
Button Layout and Customization
Extra buttons can be a game changer, especially if you use shortcuts or gaming macros. I look for a mouse with programmable buttons that I can customize to my workflow or gaming style. On left-handed mice, these buttons are positioned on the right side of the mouse, making them easy to reach with my thumb. Software that allows easy customization is a big plus in my book.
Wired vs. Wireless
Choosing between wired and wireless depends on your needs. I prefer wireless for the freedom of movement and less clutter on my desk. However, wired mice often offer lower latency, which is important if you’re a competitive gamer. Battery life and charging options are also things I consider when going wireless.
Sensitivity and DPI Settings
DPI (dots per inch) determines how sensitive the mouse is. I like a mouse that lets me adjust DPI easily so I can switch between precision tasks and faster movements. Many left-handed mice offer DPI adjustment buttons, which I find very convenient.
Build Quality and Durability
I want a mouse that will last, so build quality is essential. Solid materials, reliable switches, and a good warranty give me confidence in my purchase. Reading reviews about long-term durability helped me avoid models that tend to wear out quickly.
Price Range
Left-handed mice can vary widely in price. I set a budget but try not to compromise on comfort and features. Sometimes spending a bit more upfront saves money and frustration later. There are good options available for all budgets, so consider what features matter most to you.
Final Thoughts
Finding the right left-handed mouse took me some trial and error, but focusing on ergonomics, button layout, and customization made all the difference. Whether you’re a casual user or a gamer, there’s a left-handed mouse out there that will fit your needs perfectly. Take your time, read reviews, and if you can, test a few models to see what feels best for your hand.
I hope my buying guide helps you find a mouse that feels just right!
Author Profile
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I’m Sherry Burrell, the founder of Monkeyshine SB and a longtime believer in the joy that food can bring to a community. Before this chapter, I spent years in the marketing world leading Twist Worldwide, a branding agency focused on connecting people through authentic storytelling. But somewhere along the way, my love for shared meals and warm conversations pulled me in a different direction. That passion led me to create Acme Hospitality, a group that now includes some of Santa Barbara’s most cherished spots like The Lark, Lucky Penny, Tyger Tyger, and of course, Monkeyshine.
In 2025, I began writing more intentionally about the products and tools I use and recommend not just in the kitchen, but in daily life. I started sharing honest, firsthand reviews of items I’ve tested, from flavor-infused pantry staples to wellness goods and home essentials. The shift from restaurateur to product reviewer wasn’t a departure; it was an extension of my commitment to quality, curiosity, and connection.
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